Publications
Relevant External Publications
Authors: Kremer M(1), Burkemper N(2)
DOI: 10.1016/j.cger.2023.06.001
PMID: 38000854
Year: 2024
Rebuts the idea that skin of the aged human is not capable of healing - it is, but more slowly than younger subjects' skin.
JOURNAL OF WOUND CARE VOL 33 NO 6 SUP C JUNE 2024
Published in Journal of Wound Care, this international consensus document aims to provide updated guidance on the principles and techniques of debridement.
This paper highlights the critical importance of wound debridement for chronic wounds to heal and describes a standardised approach to debridement that can be applied across different populations, introducing the concept of integrated debridement throughout the healing period.
The primary aim of debridement is to remove microbial and non-microbial wound components, including #biofilm, devitalised tissue, cytokines, and proteases. It is vital that all wounds are regularly debrided, unless contraindicated, as this removes barriers that delay or stall healing. While there are many approaches to debridement, these vary in efficacy, resource-intensiveness, and pain.
At the heart of SolasCure's mission to improve the lives of patients suffering from chronic wounds, is Aurase Wound Gel — an easy-to-use enzymatic debrider with demonstrated ability to remove non-viable tissue, strong local and systemic safety profile, and no added pain burden on application. Aurase Wound Gel also addresses moisture imbalance, reduces risk of infection, and promotes development of granulation tissue at all stages of the wound healing journey.
Authors: Peña OA(1), Martin P(2)
DOI: 10.1038/s41580-024-00715-1
PMID: 38528155
Year: 2024
This review highlights the complexity and interplay of different biological underpinning mechanisms at work to determine wound healing after injury.
Case Study
DOI: 10.1097/01.NURSE.0001006292.75909.7f
Year: 2024
An article published in the Nursing Times impresses the importance of holistic wound assessment and the involvement of an interprofessional team in chronic wound treatment, as well as addressing all four pillars of the TIME paradigm in order for a wound to heal:
➡ T – Tissue management (Debridement); the removal of non-viable tissue
➡ I – Infection and inflammation management
➡ M – Moisture Balance, including the management of exudate
➡ E – Edge of wound (epithelialization); promoting the growth of new tissue at the wound edges to facilitate closure
Debridement is the crucial first step but carries varying levels of efficacy depending on the method used. Effective debridement proves challenging with current methods, often either slow and ineffective (e.g., hydrogels) or rapid but resource-intensive and/or painful (e.g., surgery, waterjets).
This clearly demonstrates a need for a single, safe, and easy to use debridement solution that targets all four TIME pillars and all stages of the wound healing journey; a need that we aim to meet with our investigational product, Aurase Wound Gel.
Authors: De Francesco F(1), Ogawa R(2)
DOI: 10.1007/5584_2024_815
PMID: 38842786
Year: 2024
The transition from the older classification of chronic wounds - TIME - to TIMER showcases the Regenerative component of the process which is attracting increasing interest in the scientific and clinical community.
Authors: Mihai MM(1)(2)(3), Bălăceanu-Gurău B(2), Ion A(2), Holban AM(3), Gurău CD(4),
Popescu MN(5)(6), Beiu C(1)(2), Popa LG(1)(2), Popa MI(7)(8), Dragomirescu
CC(7)(8), Preda M(8)(9), Muntean AA(7)(8), Macovei IS(8), Lazăr V(3)
DOI: 10.3390/ijms25094629
PMCID: PMC11083077
PMID: 38731848
Year: 2024
Biofilm and its behaviour in the context of chronic wounds remains of intense interest both scientifically and clinically.
Authors: Patenall BL(1), Carter KA(1), Ramsey MR(1)
DOI: 10.3390/ijms25021304
PMCID: PMC10816820
PMID: 38279304
Year: 2024
The quest for drugs that can heal wounds remains active, and unfulfilled - but much effort is being expended on trying to locate silver bullets.
Authors: Cereda E(1), Veronese N(2), Caccialanza R(1)
DOI: 10.1097/MCO.0000000000000990
PMID: 37921900
Year: 2024
A wound bed is of course part of a human body - and as well as local factors influencing wound healing, the overall nutritional and health status of the wounded human is also of direct relevance to outcomes.
Authors: Farabi B(1)(2)(3), Roster K(4), Hirani R(4), Tepper K(5), Atak MF(6), Safai
B(1)(2)(3)
DOI: 10.3390/ijms25053006
PMCID: PMC10931571
PMID: 38474251
Year: 2024
Stem cell therapy has become intensely interesting to scientists, researchers and clinicians treating diseases of older age or degeneration. As yet though the promise of this approach is unfulfilled.
Authors: Uberoi A(1), McCready-Vangi A(1), Grice EA(2)
DOI: 10.1038/s41579-024-01035-z
PMID: 38575708
Year: 2024
The wound microbiota is likely to have a profound influence on wound bed behaviour, infection and tendency to wound healing (or chronic stalled wounds).
Authors: Smart H, Sibbald RG, Goodman L, Ayello EA, Jaimangal R, Gregory JH, Akita S, Alavi A, Armstrong DG, Arputhanathan H, Bruwer F, Caul J, Chan B, Cronje F, Dofitas B, Hamed J, Harley C, Heil J, Hill M, Jahnke D, Kalina D, Kodange C, Kotru B, Kozody LL, Landis S, LeBlanc K, MacDonald M, Mark T, Martin C, Mayer D, Murphy C, Nair H, Orellana C, Ostrow B, Queen D, Rainville P, Rajhathy E, Schultz G, Somayaji R, Stacey MC, Tariq G, Weir G, Whiteside C, Yifter H, Zacharias R
DOI: 10.1097/ASW.0000000000000120
PMID: 38354304
Year: 2024
This consensus review brings together a number of experts in different countries and healthcare settings to try to find underpinning principles of care for patients with chronic wounds.
DOI: 10.1016/j.jtv.2023.06.002
PMID: 37451973
Year: 2023
A much-needed qualitative study demonstrated the profound impact of chronic wound-associated pain on individuals' quality of life and daily functioning.
Despite its significance, there is limited research on how people with chronic wounds perceive and manage pain. Thirteen interviews were conducted to explore these experiences, revealing two main themes. The first theme centred on participants' characterisation of pain and its impact on daily life, with many feeling functionally impaired. The second theme discussed coping strategies, particularly during dressing changes, emphasising the important role of healthcare professionals and family support networks while acknowledging the burden it places on everyone involved.
The paper concludes by noting that coping with pain is exhausting and contributes to poorer quality of life, with patients expressing the need for further research on dressings rather than drugs to manage pain.
Improving patients’ quality of life is a core part of our mission at SolasCure and, with Aurase Wound Gel, we aim to deliver a gentle, easy-to-use approach during dressing changes that aims to minimise additional pain. Patients should not have to accept living with chronic wound-associated pain.
DOI: 10.1111/wrr.13008
PMID: 35385594
PMCID: PMC9081155
Year: 2022
Chronic wounds affect ~100 million patients worldwide, inflicting significant pain and costing health systems around the world billions. Yet, despite the immense public health burden, innovative treatments for non-healing chronic wounds remain limited.
In 2022, the FDA highlighted the critical need for new product development to address these unmet medical needs. The agency outlined strategies to improve clinical trials, support data sharing, and foster innovation, with the goal of enhancing patient outcomes.
Yet still, healing rates remain largely unchanged, and current gold-standard methods of debridement (a prerequisite for healing) such as surgery, continue to fall short of being effective for most patients.
The prevailing mindset in the industry has been focused on ‘managing’ wounds rather than treating them. The low-risk, low-cost 510(k) pathway has contributed to incremental rather than breakthrough advancements. But there is a growing call from patients, practitioners and regulators for scalable, evidence-backed innovations that move beyond wound care to effective wound therapy.
SolasCure is powering this shift from ‘wound ‘care’ to ‘therapy’ with Aurase Wound Gel, an enzymatic debrider that can be used in all wound treatment settings, aiming to deliver better outcomes and lower costs for patients and healthcare systems.